New dapsone -based Schiff base ligands and their Nickel (II) complexes as biological active molecules: Chemical synthesis, structural elucidation and biological studies
Keywords:
Schiff base, Nickel (II) complex, Antimicrobial activityAbstract
In this investigation, the preparation and characterization of five diphenylsulphone derived Schiff base ligands, (L1- L5) using these ligands, Ni (II) complexes were synthesized. The structures of synthesized ligand and the resultant complexes were inspected using UV-Vis spectroscopy, Fourier transform infrared spectroscopy and 1H NMR. The results from the above analytical techniques shown that the complexes are in an octahedral geometry. The Schiff base ligands, and nickel complexes have been determined as potential antimicrobial. The antimicrobial activity of the synthesized Schiff base ligands and their nickel complexes under study was carried out by using the agar well diffusion method.
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References
1. S. M. Anush, B. Vishalakshi, B. Kalluraya and N. Manju, Int. J. Biol. Macromol. ,2018,119, 446.
2. S. Qiu, G. Zhu. Coordin. Chem. Rev., 2009,253, 2891.
3. D.S. Lednicer, The Organic Chemistry of Drug Synthesis, WileyPublication, New York,1980.
4. A. Biswas, L.K. Das, M.G. Drew, C. Diaz, A. Ghosh, Inorganic Chemistry,2012, 51, 10111.
5. S. Saha, S. Pal, C.J. Gómez-García, J.M. Clemente-Juan, K. Harms, H.P. Nayek, Polyhedron2014, 74, 1.
6. S.N. Ahmad, H. Bahron, A.M. Tajuddin, K. Ramasamy, Malaysian Journal of Fundamental and Applied Sciences, 2019, 15, 613.
7. A.P. Arumugam, G. Elango, S. Guhanathan, European Journal of Biomedical, 2019, 6, 375.
8. N. Zhang, Y.H. Fan, C.F. Bi, Y. Zhao, X. Zhang, D.M. Zhang, G.M. Huang, Transition Metal Chemistry, 2013, 38, 463.
9. . Raouf, S.A. Beyramabadi, S. Allameh, A. Morsali, Journal of MolecularStructure, 2019, 1179, 779.
10. J. Szklarzewicz, A. Jurowska, D. Matoga, K. Kruczała, G. Kazek, B. Mordyl, M. Papież, Polyhedron,2020, 143, 114589.
11. E.B. Poormohammadi, M. Behzad, Z. Abbasi, S.D.A. Astaneh, Journal of Molecular Structure,2020, 1205, 127603.
12. D. S. Lednicer, The Organic Chemistry of Drug Synthesis, Vol-II, Wiley Interscience Publication, New York,1980, 27, 41215
13. Colin D. Therapeutic Drugs 1, Church Livingstone 1, D13-D18, 1999, 111.
14. Flaherty John and Rebecca L.,University of California (CA 94110 USA), Pharmacotherapy publication, 1998, 831-835.
15. S. Mirdya, M.G. Drew, A.K. Chandra, A. Banerjee, A. Frontera, S. Chattopadhyay, Polyhedron,2020, 179, 114374
16. Z. Albobaledi, M.H. Esfahani, M. Behzad, A. Abbasi, Inorganica Chimica Acta,2020, 499, 119185
17. R. Bikas, P. Mirzakhani, N. Noshiranzadeh, J. Sanchiz, M.S. Krawczyk, D.A. Kalofolias, T. Lis, Inorg Chim Acta, 2020,505, 119461.
18. E. Conpolt, M. Kaya, Journal of Coordination Chemistry,2004, 7, 1217.
19. N. Raman, A. Selvan, S. Sudharsan, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2011,79(5), 873–883.
20. A. Mishra, S. Tahlan, K. Ramasamy, S.M. Lim, S.A.A. Shah, B. Narasimhan, Mini-Reviews in Medicinal Chemistry, 2020,20, 1311.
21. .V.K. Srivastava, Future Journal of Pharmaceutical Sciences, 2021, 7, 44.
22. K. Nakamotto, Infrared Spectra of Inorganic and Coordination compounds,John Wiley,New York, 1963.
23. I.Vogel, Quantitative Inorganic Analysis, Longman, Green and Co., London, 1954.
24. S.E. Turner, R.C. Anderson, Journal of the American Chemical Society,1949, 71, 912.
25. B. Tang, T. Yue, J. Wu, Y. Dong, Y. Ding, H. Wang,Talanta, 2004, 64, 955.
26. E. Tas, A. Kilic, M. Durgun, I. Yilmaz, I. Ozdemir, N. Gurbuz. Journal of OrganometallicChemistry, 2009, 694, 446.
27. G. Venkatachalam, R. Ramesh,Inorganic Chemistry Communications, 2006, 9, 703
28. R.G. Kalkhambkar, G.M. Kulkarni, C.M. Kamanavalli, N. Premkumar, S.M. Asdaq, C.M. Sun, European Journal of Medicinal Chemistry, 2008, 43, 2178.
29. J. Dundas, Z. Ouyang, J. Tseng, A. Binkowski, Y. Turpaz, J. Liang, Nucleic Acids Research, 2006, 34, 116.
30. R.A. Laskowski, M.B. Swindells, Journal of Chemical Model, 2011, 51, 2778.
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